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An allosamizoline/glucosamine hybrid NAGase inhibitor

TitleAn allosamizoline/glucosamine hybrid NAGase inhibitor
Publication TypeJournal Article
Year of Publication1997
AuthorsKnapp, S, Kirk, BA, Vocadlo, D, Withers, SG
JournalSYNLETT
Pagination435-&
Date PublishedMAY
ISSN0936-5214
Abstract

The glucosamine isothiourea derivative 7, which resembles the aminocyclitol isourea portion of the chitinase inhibitor allosamidin (5), inhibits jack bean NAGase with K-i = 160 mu M.