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Substituted glycals as probes of glycosidase mechanisms

TitleSubstituted glycals as probes of glycosidase mechanisms
Publication TypeJournal Article
Year of Publication1996
AuthorsLai, ECK, Morris, SA, STREET, IP, Withers, SG
JournalBIOORGANIC & MEDICINAL CHEMISTRY
Volume4
Pagination1929-1937
Date PublishedNOV
ISSN0968-0896
Abstract

{D-Glucal and a series of substituted derivatives have been tested as substrates, inhibitors and inactivators of the Agrobacterium faecalis beta-glucosidase in order to probe structure/function relationships in this enzyme. D-Glucal is shown to be a substrate (k(cat)=2.3 min(-1)

DOI10.1016/S0968-0896(96)00175-7