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NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus

TitleNMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus
Publication TypeJournal Article
Year of Publication2000
AuthorsFyfe, CA, Grondey, H, Blazek-Welsh, AI, Chopra, SK, Fahie, BJ
JournalJournal of Controlled Release
Volume68
Pagination73-83
Date PublishedJul
Type of ArticleArticle
ISBN Number0168-3659
KeywordsBEHAVIOR, CONTROLLED RELEASE, flow NMR imaging, GEL LAYER, HPMC TABLETS, RELEASE DOSAGE FORMS, USP Apparatus 4
Abstract

A system for performing NMR imaging experiments on drug delivery devices within a how-through dissolution apparatus, USP Apparatus 4, has been developed. The system was used to image the physical changes that occur in solid dosage forms during dissolution in the Row-through apparatus. Simultaneous cumulative drug release measurements were also made. The NMR images obtained under these conditions and the drug release data provide a better understanding of the processes involved in the release of drugs from drug delivery systems based on diffusion, dissolution and osmosis mechanisms. (C) 2000 Elsevier Science B.V. All rights reserved.
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