|Title||Nickel-Catalyzed Csp(2)-Csp(3) Bond Formation by Carbon-Fluorine Activation|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Sun, AD, Leung, K, Restivo, AD, LaBerge, NA, Takasaki, H, Love, JA|
|Journal||CHEMISTRY-A EUROPEAN JOURNAL|
|Date Published||MAR 10|
We report herein a general catalytic method for Csp(2)Csp(3) bond formation through CF activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with -hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks.