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Nickel-Catalyzed Csp(2)-Csp(3) Bond Formation by Carbon-Fluorine Activation

TitleNickel-Catalyzed Csp(2)-Csp(3) Bond Formation by Carbon-Fluorine Activation
Publication TypeJournal Article
Year of Publication2014
AuthorsSun, AD, Leung, K, Restivo, AD, LaBerge, NA, Takasaki, H, Love, JA
JournalCHEMISTRY-A EUROPEAN JOURNAL
Volume20
Pagination3162-3168
Date PublishedMAR 10
ISSN0947-6539
Abstract

We report herein a general catalytic method for Csp(2)Csp(3) bond formation through CF activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with -hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks.

DOI10.1002/chem.201303809