|Title||A new carceplex, and a crystal structure and dynamic combinatorial chemistry of a carceplex|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Sun, JY, Patrick, BO, Sherman, JC|
|Type of Article||Article|
|Keywords||carceplex, Disulfide, Dynamic combinatorial chemistry, Guest release, HEMICARCEPLEXES, MOLECULES, supramolecular, TEMPLATION|
A new carceplex (2-guest) is reported. It is composed of two cavitands linked by four disulfide bonds. It forms twistomers, which interconvert on a millisecond timescale. The energy barrier for interconversion of twistomers is guest-dependent. Formation of carceplex 2-guest is template dependent. The selectivity in templates is flat relative to most previous related template work. Larger kin carceplex 1.guests were reinvestigated. A crystal structure confirms the twist between the hemispherical cavitands. Use of a redox buffer allowed dynamic combinatorial chemistry to be performed between pairs of templates. (C) 2009 Elsevier Ltd. All rights reserved.
|URL||<Go to ISI>://000269098700012|