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MOLECULAR PROBES Getting lucky in the lysosome

TitleMOLECULAR PROBES Getting lucky in the lysosome
Publication TypeJournal Article
Year of Publication2010
AuthorsGoddard-Borger, ED, Wennekes, T, Withers, SG
JournalNATURE CHEMICAL BIOLOGY
Volume6
Pagination881-883
Date PublishedDEC
ISSN1552-4450
Abstract

Conjugation of a known, mechanism-based glycosidase inhibitor to sensitive fluorophores yielded unexpectedly potent and selective probes for quantifying active lysosomal glucocerebrosidase. These conjugates could prove to be invaluable tools for diagnosing and studying Gaucher disease.

DOI10.1038/nchembio.470