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Mechanisms Of Unusual Transformations Involving Organophosphonate Natural Products Mediated By Non-Heme Iron Dependent Oxygenases

Tuesday, October 26, 2021 - 12:45 to 14:00
Dr. David L. Zechel | Distinguished Organic Lecture
Department of Chemistry, Queen’s University
Event Category: 
LMC - Lectures in Modern Chemistry
Dr. Martin Tanner
Chemistry B250


Organophosphonates (Pns) comprise a prominent class of natural products that is defined by a highly stable C-P bond. The biochemistry of Pns has evolved into two worlds, with one dedicated to synthesizing the C−P bond and incorporating this motif into complex bioactive molecules, while the other seeks to cleave the C−P bond to release inorganic phosphate, a life limiting nutrient. Non-heme iron dependent oxygenases play important roles in both biosynthetic and catabolic Pn pathways. This seminar will cover (1) recent mechanistic studies into the oxidative C-P bond cleavage reaction catalyzed by the mixed valence diiron oxygenase, PhnZ, and (2) the unusual transformations catalyzed by a non-heme iron / alpha-ketoglutarate dependent oxygenase during the biosynthesis of the fungal metabolite, Fosfonochlorin.