Title | L-Idoseptanosides: substratesd D-glucosidases? |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Tauss, A, Steiner, AJ, Stutz, AE, Tarling, CA, Withers, SG, Wrodnigg, TM |
Journal | TETRAHEDRON-ASYMMETRY |
Volume | 17 |
Pagination | 234-239 |
Date Published | JAN 23 |
ISSN | 0957-4166 |
Abstract | Based on the reported glycosidase inhibitory activities of 1,6-dideoxy-1,6-imino-L-iditol, the corresponding aryl glycosides 4-nitrophenyl alpha- and beta-L -idoseptano side 7 and 8 were synthesised as possible glycosidase substrates. Despite their inherently larger size, these septanosides were indeed shown to be glycosidase substrates, albeit weak ones. In addition, these two substrate analogues 7 and 8 also demonstrated a remarkable degree of selectivity for beta- and alpha-glucosidases, respectively. (c) 2005 Elsevier Ltd. All rights reserved. |
DOI | 10.1016/j.tetasy.2005.12.007 |
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