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Hydroaminoalkylation: Early-Transition-Metal-Catalyzed alpha-Alkylation of Amines

TitleHydroaminoalkylation: Early-Transition-Metal-Catalyzed alpha-Alkylation of Amines
Publication TypeJournal Article
Year of Publication2014
AuthorsChong, E, Garcia, P, Schafer, LL
JournalSynthesis-Stuttgart
Volume46
Pagination2884-2896
Date PublishedNOV
ISSN0039-7881
Abstract

The recent development and progress of early-transition-metal-catalyzed C-H alkylation adjacent to nitrogen of unprotected amines with alkenes are summarized. Group 4 and 5 metal complexes are very effective for hydroaminoalkylation catalysis, an emerging atom-economic C(sp(3))-C(sp(3)) bond formation strategy. 1Introduction 2Group 4 Hydroaminoalkylation Catalysis 2.1Intramolecular Hydroaminoalkylation 2.2Intermolecular Hydroaminoalkylation 3Group 5 Hydroaminoalkylation Catalysis 4Conclusions and Outlook

DOI10.1055/s-0034-1379216