| Title | Gold(I)-Catalyzed Intramolecular Tandem Addition/Friedel-Crafts Reactions between Acyclic Enamides and 1-Arylalkynes. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Kozak, JA, Patrick, BO, Dake, GR |
| Journal | Journal of Organic Chemistry |
| Volume | 75 |
| Pagination | 8585 - 8590 |
| Date Published | 2010/// |
| ISBN Number | 0022-3263 |
| Keywords | amidoindene prepn, enamide arylalkyne addn Friedel Craft reaction gold catalyst |
| Abstract | Electron-deficient acyclic enamine derivs. react with electron-rich 1-arylalkynes using cationic gold(I) species as catalysts in an intramol. process to form annulated 1-amido-substituted indene derivs., e.g., I as the major products. Yields for this process range between 21% and 98%. In some cases, a two-step process that includes a subsequent alkene isomerization is needed. [on SciFinder(R)] |
