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Glycosidase mechanisms

TitleGlycosidase mechanisms
Publication TypeJournal Article
Year of Publication2000
AuthorsRye, CS, Withers, SG
JournalCURRENT OPINION IN CHEMICAL BIOLOGY
Volume4
Pagination573-580
Date PublishedOCT
ISSN1367-5931
Abstract

Insights into glycosidase mechanisms have come from X-ray crystallographic studies on complexes with substrate analogs and inhibitors, representing all the intermediate species along the reaction coordinate. Site-directed mutagenesis continues to play a significant role in understanding mechanisms, but is also proving important in generating glycosidases of modified mechanism or specificity.

DOI10.1016/S1367-5931(00)00135-6