| Title | Formal Synthesis of (+/-)-Tetrodotoxin via the Oxidative Amidation of a Phenol: On the Structure of the Sato Lactone |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Xu, S, Ciufolini, MA |
| Journal | ORGANIC LETTERS |
| Volume | 17 |
| Pagination | 2424-2427 |
| Date Published | MAY 15 |
| ISSN | 1523-7060 |
| Abstract | A formal total synthesis of (+/-)-tetrodotoxin that relies on the bimolecular oxidative amidation of a phenol is described, and a structural correction of the Sato lactone, an important tetrodotoxin intermediate, is provided. This work lays the foundation for an ultimate enantioselective synthesis. |
| DOI | 10.1021/acs.orglett.5b00935 |
