| Title | Evaluation of tetraphenyl-2,3-dihydroxychlorins as potential photosensitizers |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Macalpine, JK, Boch, R, Dolphin, D |
| Journal | Journal of Porphyrins and Phthalocyanines |
| Volume | 6 |
| Pagination | 146-155 |
| Type of Article | Article |
| ISBN Number | 1088-4246 |
| Keywords | AGGREGATION, BACTERIOCHLORINS, beta, beta-dihydroxychlorins, BIODISTRIBUTION, chlorins, cytotoxicity, DERIVATIVES, photodynamic, PHOTODYNAMIC THERAPY, PHOTOPHYSICAL PROPERTIES, PHOTOSENSITIZERS, porphyrins, PROTEIN-BINDING, SENSITIZERS, therapy, TUMOR PHOTOSENSITIZERS |
| Abstract | A series of beta,beta-dihydroxychlorins derived from meso-tetraphenylporphyrins (TPPs) have been synthesized. Their in vitro cytotoxicity has been measured and compared to BPDMA (verteporfin). Under the assay conditions BPDMA had an LD50 (lethal dose to kill 50% of cells) value of 0.007 muM (5 ng/mL). The LD50 values for the TPP derivatives varied from 1.7 x 10(-2) to 9.9 muM depending upon the substituents and their position on the phenyl groups. One example of the dihydroxychlorin prepared from unsubstituted 5,15-diphenylporphyrin was examined and this exhibited an LD50 of 2.4 x 10(-3) muM! Copyright (C) 2002 Society of Porphyrins & Phthalocyanines. |
| URL | <Go to ISI>://000178134600008 |
