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An effective synthetic route to EF5

TitleAn effective synthetic route to EF5
Publication TypeJournal Article
Year of Publication1998
AuthorsBaird, IR, Skov, KA, James, BR, Rettig, SJ, Koch, CJ
JournalSynthetic Communications
Volume28
Pagination3701-3709
Type of ArticleArticle
ISBN Number0039-7911
KeywordsANTIBODIES, BINDING, CELLS, COMPLEXES, CRYSTAL, HYPOXIA, TUMORS
Abstract

EF5 (a 2-nitroimidazole containing an N-(pentafluoropropyl) acetamide substituent) is a very sensitive probe for quantifying the amount of hypoxia within cells; a much improved, short step, synthetic procedure is described for EF5, whose X-ray structure is also presented.

URL<Go to ISI>://000075780100021