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The effect of organotin compounds on the permeability of model biological membranes

TitleThe effect of organotin compounds on the permeability of model biological membranes
Publication TypeJournal Article
Year of Publication1997
AuthorsCullen, WR, Herring, FG, Nwata, BU
JournalApplied Organometallic Chemistry
Volume11
Pagination369-379
Date PublishedMay
Type of ArticleProceedings Paper
ISBN Number0268-2605
Keywordsbilayer, DIMETHYLARSINIC ACID, efflux, egg, ERYTHROCYTE, EXCHANGE, facilitated diffusion, LIPOSOMES, membrane modification, monobutyltin, NMR, PHOSPHATIDYLCHOLINE, tributyltin chloride, trichloride
Abstract

The efflux of dimethylarsinic acid (DMA) from liposomes formed from egg phosphatidylcholine (EPC) is increased when tributyltin chloride (TBT) is added to the extraliposomal compartment; however the addition of monobutyltin trichloride (MBT) slows down the efflux. When the liposomes are prepared from EPC and organotin compounds, different mechanisms for DMA efflux seem to operate: TBT-EPC liposomes show a mixture of facilitated and passive diffusion; MBT-EPC liposomes show only passive diffusion. The facilitated diffusion of DMA(-) seems to be stopped by the addition of TBT to the extraliposomal compartment. (C) 1997 by John Wiley & Sons, Ltd.

URL<Go to ISI>://A1997WZ73300003