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Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly

TitleDynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly
Publication TypeJournal Article
Year of Publication2019
AuthorsFu, L, Haage, A, Kong, N, Tanentzapf, G, Li, H
JournalCHEMICAL COMMUNICATIONS
Volume55
Pagination5235-5238
Date PublishedMAY 8
ISSN1359-7345
Abstract

We report the engineering of a protein-based dynamic hydrogel that can be reversibly tuned between stiff and soft states via a redox reaction. When cultured on this hydrogel surface, human lung fibroblasts can dynamically and reversibly change their morphology in response to changes in hydrogel stiffness.

DOI10.1039/c9cc01276a