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Disabling Molecular Recognition through Reversible Mechanical Stoppering

TitleDisabling Molecular Recognition through Reversible Mechanical Stoppering
Publication TypeJournal Article
Year of Publication2019
AuthorsSoto, MA, MacLachlan, MJ
JournalORGANIC LETTERS
Volume21
Pagination1744-1748
Date PublishedMAR 15
Type of ArticleArticle
ISSN1523-7060
Abstract

Mechanical stoppering of a guest molecule prevents its self-assembly with a macrocycle unit, so that both species coexist in a medium but do not recognize each other. The application of a chemical or physical stimulus reverses mechanical stoppering and subsequently enables molecular recognition. This process, which occurs without cross-reactivity and is perceptible at the macroscopic scale, could facilitate programming on/off states in supramolecular materials and molecular devices.

DOI10.1021/acs.orglett.9b00310