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Dentigerumycin F and G: Dynamic structures retrieved through a genome-mining/nitrogen-NMR methodology

TitleDentigerumycin F and G: Dynamic structures retrieved through a genome-mining/nitrogen-NMR methodology
Publication TypeJournal Article
Year of Publication2022
AuthorsMorgan, KD, Williams, DE, Ryan, KS, Andersen, RJ
JournalTetrahedron Letters
Volume94
Pagination153688
ISSN0040-4039
KeywordsGenome mining, Natural product discovery, Nitrogen-15, NMR-guided discovery, Piperazic acid
Abstract

Continual efforts to unearth new natural product chemistry expands our understanding of the scope of chemical space. Here we report the two low-abundance piperazic acid-containing linear peptides dentigerumycins F (1) and G (2), discovered through a combined genome-mining/15N NMR-based discovery method. Dentigerumycins F and G demonstrate a dynamic equilibrium in their oxane ring systems, which complicated structure elucidation. The application of various NMR solvents and conditions revealed the constitution of these natural products.
URLhttps://www.sciencedirect.com/science/article/pii/S0040403922000739
DOI10.1016/j.tetlet.2022.153688