|Title||Crystal engineering for absolute asymmetric synthesis through the use of meta-substituted aryl groups|
|Publication Type||Journal Article|
|Year of Publication||1997|
|Authors||Wu, LC, Cheer, CJ, Olovsson, G, Scheffer, JR, Trotter, J, Wang, SL, Liao, FL|
|Type of Article||Article|
|Keywords||DERIVATIVES, PHOTOCHEMISTRY, PHOTOREARRANGEMENT|
A significant tendency towards crystallization in chiral space groups has been found for 4-benzyloxy-2-pyridones whose phenyl groups are meta-substituted (m-Cl, m-Br, m-Me and m-OMe). Irradiation of single crystals of three of these materials leads to optically active beta-lactam derivatives in high chemical and optical yields via an allowed disrotatory electrocyclization. (C) 1997 Elsevier Science Ltd.
|URL||<Go to ISI>://A1997WW95800004|