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Correlation of photosensitizer delivery to lipoproteins and efficacy in tumor and arthritis mouse models; comparison of lipid-based and Pluronic P123 formulations

TitleCorrelation of photosensitizer delivery to lipoproteins and efficacy in tumor and arthritis mouse models; comparison of lipid-based and Pluronic P123 formulations
Publication TypeJournal Article
Year of Publication2003
AuthorsChowdhary, RK, Sharif, I, Chansarkar, N, Dolphin, D, Ratkay, L, Delaney, S, Meadows, H
JournalJournal of Pharmacy and Pharmaceutical Sciences
Volume6
Pagination198-204
Date PublishedMay-Aug
Type of ArticleArticle
ISBN Number1482-1826
KeywordsAGGREGATION, PLASMA-LIPOPROTEINS, SURFACTANTS
Abstract

The purpose of this study was the use of animal models to demonstrate the importance of drug delivery (verteporfin) to plasma lipopropteins in order to attain efficacy of photodynamic therapy (PDT) in vivo. METHODS. Photosensitzers appropriately formulated in various vehicles such as pluronics and lipid-based systems were compared to delivery of the drug in DMSO in two in vivo systems. The first was a tumor model using male DBA/2 mice inoculated intradermally with M1 rhabdomyosarcoma cells and in the second, arthritis in the MRL-lpr mouse strain was enhanced by two intradermal injections of complete Freunds adjunct. RESULTS. Those formulations in which the drug was in a monomeric form were better able to transfer drug to lipoproteins, which in turn led to superior PDT in vivo. CONCLUSIONS. The ability to introduce drug in monomeric form into the circulation correlates well with efficacy of photosensitizer formulations in mouse arthritis and tumor models.

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