Congratulations the Perrin Group! The Perrin Lab's work on new approaches to fluorination for PET imaging makes the cover of Acc. Chem. Research - One quick step for 18F-labeling, one large step for PET Imaging.” Organoborates react rapidly with 18F-fluoride ion in water to afford 18F-labeled organotrifluoroborates; this enables single-step 18F labeling of molecularly complex ligands to create new PET imaging agents. Key to this technological advance has been the fundamental understanding of the kinetic stability of organotrifluoroborates toward solvolysis at neutral pH.
For more information please see: http://pubs.acs.org/toc/achre4/49/7