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Bis(amidate) titanium precatalyst for the intermolecular hydroamination of allenes

TitleBis(amidate) titanium precatalyst for the intermolecular hydroamination of allenes
Publication TypeJournal Article
Year of Publication2006
AuthorsAyinla, RO, Schafer, LL
JournalInorganica Chimica Acta
Volume359
Pagination3097-3102
Date PublishedJun
Type of ArticleArticle
ISBN Number0020-1693
KeywordsALKENES, allenes, amidate ligands, AMIDO COMPLEXES, CATALYST, CYCLIZATION, HYDROAMINATION, IMIDO COMPLEXES, INTRAMOLECULAR HYDROAMINATION, NITROGEN-HETEROCYCLES, ORGANOLANTHANIDE-CATALYZED HYDROAMINATION, precatalyst, TERMINAL ALKYNES, titanium complex, UNPROTECTED AMINO OLEFINS, VINYLARENES
Abstract

A bis(amidate)-bis(amido) titanium complex (5) is an efficient precatalyst for the regioselective intermolecular hydroamination of substituted allenes. Arylamines react quickly with a 5 mol% precatalyst loading at 90 degrees C to give the ketimine product, which can be reduced to give substituted amines. With precatalyst loading of 10 mol% and temperatures of 120 degrees C alkyl amines can be used as viable substrates for the hydroamination of substituted allenes. (c) 2006 Elsevier B.V. All rights reserved.

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