Title | Biologically active branched-chain aminocyclopentane tetraols from d-galactose |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Schalli, M, Weber, P, Nasseri, SA, Gomez, ATorvisco, Mueller, P, Stuetz, AE, Withers, SG, Wolfsgruber, A, Wrodnigg, TM |
Journal | MONATSHEFTE FUR CHEMIE |
Volume | 150 |
Pagination | 861-870 |
Date Published | MAY |
ISSN | 0026-9247 |
Abstract | From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a series of highly functionalized branched-chain cyclopentanes was easily available. The initial partially protected cyclopentane tetraol is a versatile central intermediate and was exploited as subject to various highly regio- and stereoselective structural alterations with a view to prepare selective -d-galactosidase inhibitors. In line with our findings on recently reported constitutional isomers featuring amino substituents, basic derivatives are medium activity inhibitors of -d-galactosidases with side activities for beta-glucosidases. {[}GRAPHICS] . |
DOI | 10.1007/s00706-019-02428-0 |
