| Title | Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Gloster, TM, Williams, SJ, Roberts, S, Tarling, CA, Wicki, J, Withers, SG, Davies, GJ |
| Journal | CHEMICAL COMMUNICATIONS |
| Pagination | 1794-1795 |
| ISSN | 1359-7345 |
| Abstract | The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding. |
| DOI | 10.1039/b405152a |
