| Title | Approach to Tetrodotoxin via the Oxidative Amidation of a Phenol |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Mendelsohn, BA, Ciufolini, MA |
| Journal | Organic Letters |
| Volume | 11 |
| Pagination | 4736-4739 |
| Date Published | Oct |
| Type of Article | Article |
| ISBN Number | 1523-7060 |
| Abstract | An approach to tetrodotoxin that relies on the oxidative amidation of methyl 4-hydroxyphenylacetate as a key step is described. The stereoselective Introduction of a beta-hydroxynitrile functionality on one of the double bonds of the emerging dienone is achieved through an intramolecular nitrile oxide cycloaddition-fragmentation sequence. |
| DOI | 10.1021/ol901914u |
