|Title||Approach to Tetrodotoxin via the Oxidative Amidation of a Phenol|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Mendelsohn, BA, Ciufolini, MA|
|Type of Article||Article|
An approach to tetrodotoxin that relies on the oxidative amidation of methyl 4-hydroxyphenylacetate as a key step is described. The stereoselective Introduction of a beta-hydroxynitrile functionality on one of the double bonds of the emerging dienone is achieved through an intramolecular nitrile oxide cycloaddition-fragmentation sequence.