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Anti-Markovnikov intermolecular hydroamination: A bis(amidate) titanium precatalyst for the preparation of reactive aldimines

TitleAnti-Markovnikov intermolecular hydroamination: A bis(amidate) titanium precatalyst for the preparation of reactive aldimines
Publication TypeJournal Article
Year of Publication2003
AuthorsZhang, Z, Schafer, LL
JournalOrganic Letters
Volume5
Pagination4733-4736
Date PublishedNov
Type of ArticleArticle
ISBN Number1523-7060
KeywordsALKENES, CATALYTIC HYDROAMINATION, COMPLEXES, LIGAND, SCOPE, TERMINAL ALKYNES
Abstract

A bulky bis(N-2’,6’-diisopropylphenyi(phenyl)-amidate)titanium-bis(diethylamido) complex was identified as a highly active and regloselective precatalyst for the anti-Markovnikov hydroamination of a wide range of terminal alkyl alkynes; with alkylamines. This titanium complex was fully characterized, including its X-ray crystal structure. The reactive aldimine products generated have been further elaborated using one-pot procedures to give substituted amines, aidehydes, and the isoquinoline framework.

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