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Aggregation studies of benzoporphyrin derivative

TitleAggregation studies of benzoporphyrin derivative
Publication TypeJournal Article
Year of Publication2001
AuthorsDelmarre, D, Hioka, N, Boch, R, Sternberg, E, Dolphin, D
JournalCanadian Journal of Chemistry-Revue Canadienne De Chimie
Volume79
Pagination1068-1074
Date PublishedMay
Type of ArticleArticle
ISBN Number0008-4042
KeywordsAGGREGATION, benzoporphyrin, BPD, DERIVATIVE, DIMERIZATION, FLUORESCENCE, PHOTODYNAMIC THERAPY, PHOTOSENSITIZERS, porphyrins, SPECTROSCOPY, therapy
Abstract

The photophysical properties of a ring B benzoporphyrin derivative 1,3-diene dimethylester were investigated in solution (water-DMSO mixtures). At low proportions of water in DMSO, the diester obeys Beer’s law at all pH values and ionic strengths investigated. For solvent systems containing more than 30% water, the extent of deviation from Beer’s law as a function of porphyrin concentration is attributed to formation of porphyrin dimers. Dimerization equilibrium constants (Kd) have been determined in different percentage of solvent mixtures, using absorption and fluorescence spectroscopies, and were found to exhibit a linear correlation between log (Kd) and the inverse of the dielectric constant (log (Kd) = 24.6 - 1060.4 x 1/epsilon (mix)). This equation permits the calculation of Kd in mixtures of water-DMSO.

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