Abstract:
Standardizing kinetic analysis across our late stage portfolio has enabled efficient process optimization and characterization via improved mechanistic understanding. A key contributor to the success of this approach has been to deploy process analytical technologies (PAT) for in-situ reaction monitoring to collect continuous time course data throughout the course of each chemical reaction. We have automated reaction monitoring and kinetic analysis through implementation of a templated approach based on Reaction Progress Kinetic Analysis (RPKA). This has facilitated the collection of continuous kinetic data by scientists across a range of experience levels and allowed detailed mechanistic analysis for use in predictive kinetic modeling.