Research & Teaching Faculty

Default Header Image

2-Pyridonate Titanium Complexes for Chemoselectivity. Accessing Intramolecular Hydroaminoalkylation over Hydroamination

Title2-Pyridonate Titanium Complexes for Chemoselectivity. Accessing Intramolecular Hydroaminoalkylation over Hydroamination
Publication TypeJournal Article
Year of Publication2013
AuthorsChong, E, Schafer, LL
JournalOrganic Letters
Volume15
Pagination6002-6005
Date PublishedDEC 6
ISSN1523-7060
Abstract

Chemoselectivity of intramolecular hydroaminoalkylation over hydroamination has been achieved with a bis(3-phenyl-2-pyridonate) titanium complex. Primary aminoalkenes are selectively alpha-alkylated by C-H functionalization adjacent to nitrogen to access five- and six-membered cycloalkylamines with a good substrate-dependent diastereoselectivity of up to 19:1.

DOI10.1021/ol402890m