Research & Teaching Faculty

Default Header Image

2-Pyridonate Tantalum Complexes for the Intermolecular Hydroaminoalkylation of Sterically Demanding Alkenes

Title2-Pyridonate Tantalum Complexes for the Intermolecular Hydroaminoalkylation of Sterically Demanding Alkenes
Publication TypeJournal Article
Year of Publication2014
AuthorsChong, E, Brandt, JW, Schafer, LL
JournalJournal of the American Chemical Society
Volume136
Pagination10898-10901
Date PublishedAUG 6
ISSN0002-7863
Abstract

The design and synthesis of a mixed 2-pyridonate-Ta(NMe2)(3)Cl complex for the direct C-H alkylation adjacent to nitrogen in unprotected secondary amines are reported. The hydroaminoalkylation of sterically demanding internal alkenes gives the direct, catalytic formation of C(sp(3))-C(sp(3)) bonds. Substrate scope investigations reveal key strategies for further catalyst development efforts in this 100% atom-economic synthesis of alpha-alkylated amines.

DOI10.1021/ja506187m