| Title | 2-Pyridonate Tantalum Complexes for the Intermolecular Hydroaminoalkylation of Sterically Demanding Alkenes |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Chong, E, Brandt, JW, Schafer, LL |
| Journal | Journal of the American Chemical Society |
| Volume | 136 |
| Pagination | 10898-10901 |
| Date Published | AUG 6 |
| ISSN | 0002-7863 |
| Abstract | The design and synthesis of a mixed 2-pyridonate-Ta(NMe2)(3)Cl complex for the direct C-H alkylation adjacent to nitrogen in unprotected secondary amines are reported. The hydroaminoalkylation of sterically demanding internal alkenes gives the direct, catalytic formation of C(sp(3))-C(sp(3)) bonds. Substrate scope investigations reveal key strategies for further catalyst development efforts in this 100% atom-economic synthesis of alpha-alkylated amines. |
| DOI | 10.1021/ja506187m |
