Abstract:
Substituted chiral aziridines when reacted with active methylene compounds in the presence of catalytic amount of Lewis acid produced enantiomerically pure γ-lactams and dihydropyrroles via domino ring opening-cyclization. When Donor-Acceptor (DA)-cyclopropanes were taken as the substrate in place of aziridines, corresponding carbocyclic compounds were generated in diastereomerically pure form.
A new method for the synthesis of perfluoroalkenes via atom transfer radical addition-elimination under photoredox catalysis was also developed.