Keng Chou

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Keng Chou

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Research and Teaching Interests

Our research is devoted to the application of nonlinear optical spectroscopy in surface chemistry, materials science and biophysical chemistry:

(I) Nanoscale Far-field Microscopy for Research in Biological and Material Science

Because of the diffraction limit, the resolution of a far-field fluorescent microscope is limited to 200-300 nm, which makes it unable to resolve many fine structures. We have developed a two-photon excitation fluorescence (2PEF) microscope with 55-nm resolution. We study biological and material science problems with the nanoscale optical microscope.

(II) Oilsands Surface Chemistry

Canada’s oilsands reserves, which are estimated at 175 billion barrels, place Canada second in the world ranking of crude oil reserves. However, the large amount of water used in current bitumen extraction processes is a great concern, particularly as the industry is expected to grow over the next 20 years. Our research objective is to understand the competition adsorption of solvents, water, and bitumen on mineral materials to provide molecular-level information for developing a more environment-friendly extraction process. This research project is funded by the Imperial Oil-Alberta Ingenuity Centre for Oil Sands Innovation. More information can be found at www.cosi.ca

Videos about the Alberta oil sands

 

(III) Surface Properties of Materials

Surface properties of materials are often different from those for the bulk, and they play an important role in many natural and industrial processes. The surfaces of polymers, for example, have very different molecular structures from the bulks. These structural differences can lead to different phase transition properties and different optical and electronic properties.

(IV) Surface Chemistry at Aqueous and Electrochemical Interfaces

As water is often considered the most important solvent, a molecular-level understanding of aqueous interfaces is critical for understanding many environmental, chemical and biological processes. However, because of the difficulties to probe a buried aqueous interface, our understanding of the buried aqueous interface is still limited. Our group uses sum frequency generation vibrational spectroscopy to probe the structures of water molecules and their interactions with the substrates.

Financial supports for graduate students available

Interested students already accepted by UBC may email me directly. Prospective graduate students should visit this link , submit your application to UBC, and contact me by email.

Recent Publications:

30. "Complex Formations Between Surfactants and Polyelectrolytes of the Same Charge On Water Surface", A. Mafi, D. Hu, and K. C. Chou, Langmuir, 33 (32), pp 7940–7946 (2017)

29. "Transient Phase of Ice Observed by Sum Frequency Generation at the Water/Mineral Interface During Freezing", K. A. Lovering, A. K. Bertram, and K. C. Chou, J. Phys. Chem. Lett., (2017) PDF

28. "Ringing phenomenon in chaotic microcavity for high-speed ultra-sensitive sensing" L. Chen, Q. Liu, W. Zhang, and K. C. Chou, Scientific Reports, 38922 (2016) PDF

27. "Interactions of sulfobetaine zwitterionic surfactants with water on water surface" A. Mafi, D. Hu, K. C. Chou, Langmuir, 32 (42), pp 10905–10911 (2016) PDF

26. “Real-time 3D stabilization of a super-resolution microscope using an electrically tunable lens, R. Tafteh, L. Abraham, D. Seo, H. Y. Lu, M. R. Gold, and K. C. Chou, Optics Express, 24, 22959. (2016) PDF

25. "New Information on the Ion-Identity Dependent Structure of Stern Layer Revealed by Sum Frequency Generation Vibrational Spectroscopy", K. A. Lovering, A. K. Bertram, and K. C. Chou, J. Phys. Chem. C, 120 (32), 18099–18104 (2016) PDF

24. "In-line polarization rotator based on the quantum-optical analogy", L. Chen, K. Qu, H. Shen, W. Zhang, K. C. Chou, Q. Liu, T. Yan, B Wang, and S. Wang, Opt. Lett.  41 (9), 2113-2116 (2016) PDF

23. "Revisit the Thermodynamics of Water Surface in the Presence of Surfactants", D. Hu, A. Mafia, K. C. Chou, J. Phys. Chem. B. 120 (9), 2257–2261 (2016) PDF

22. "Interactions of water with the nonionic surfactant polyoxyethylene glycol alkyl ethers studied by phase-sensitive sum frequency generation and molecular dynamics simulation", A. Mafia, D. Hu, K. C. Chou, Surface Science, 648, 366–370 (2016)PDF

21. "Single Molecule Localization Deep Within Thick Cells; A Novel Super-Resolution Microscope", Tafteh, R. ; Scriven, D. R. L. ; Moore, E. D. W. ; Chou, K. C , Journal of Biophotonics ,9 (1-2), 155–160 (2016) PDF

20. "Surface charge at bitumen/water interface investigated by phase-sensitive sum frequency generation vibrational spectroscopy- effects of pH, ions, and surfactants", D. Hu, K. C. Chou, Energy & Fuels, 29 (12), 7885–7888 (2015) PDF

19. "Binary Solvents With Ethanol For Effective Bitumen Displacement At Solvent/mineral Interfaces", Yang, Z. ; Nikakhtari, H. ; Wolf, S. ; Hu, D. ; Gray, M. R. ; Chou, K. C. , Energy & Fuels, 29 (7), 4222–4226 (2015) PDF

18. "Local pH tracking in living cells", C. Tsou, C. Hsia, J. Chu, Y. Hung, Y. Chen, F. Chien, K. C. Chou, P. Chen and C. Mou, Nanoscale, 7, 4217 (2015) PDF

17. "Re-Evaluating The Surface Tension Analysis Of Polyelectrolyte-Surfactant Mixtures Using Phase-Sensitive Sum Frequency Generation Spectroscopy", D. Hu, K. C. Chou, Journal of the American Chemical Society (Communication), 136, 15114-15117 (2014) PDF

16. "Adhesion Investigation Between Metal and Benzocyclobutene (BCB) Polymer Dielectric Materials in 3-D Integration Applications", J. Shih, W. Huang, C. Ko, Z. Yang, S. Hu, J. Leu, K. C. Chou, and K. Chen, IEEE Trans. Device Mater. Rel., 14 (3), 914 (2014) PDF

15. "Interactions of Polyelectrolytes with Water and Ions at Air/Water Interfaces Studied by Phase-Sensitive Sum Frequency Generation Vibrational Spectroscopy", D. Hu, Z. Yang and K. C. Chou, J. Phys. Chem. C, 2117 (30), 15698, (2013) PDF

14. "Investigation of sub-100 nm gold nanoparticles for laser-induced thermotherapy of cancer", J. P. Leung, S. Wu, K. C. Chou, and Ruth Signorell,Nanomaterials, 3 (1), 86 (2013) PDF

13. "The Role of Interfacial Water on Protein Adsorption at Cross-linked Polyethylene Oxide Interfaces', B. O. Leung, Z. Yang, S. S. H. Wu, and K. C. Chou,Langmuir, 28 (13), 5724 (2012) PDF

12. "Review of Super-Resolution Fluorescence Microscopy for Biology", B. O. Leung and K. C. Chou, Appl. Spectrosc., 65 (9), 967 (2011) PDF

11. "Why Do Sulfuric Acid Coatings Influence the Ice Nucleation Properties of Mineral Dust Particles in the Atmosphere?", Z. Yang, A. K. Bertram, and K. C. Chou, J. Phys. Chem. Lett., 2 , 1232 (2011) PDF

10. "Structures of Water Molecules at Solvent/Silica Interfaces", Z. Yang, Q. Li, M. Gray, and K. C. Chou, Langmuir, 26 (21), 16397 (2010) PDF

9. "Sub-diffraction-limit Two-photon Fluorescence Microscopy for GFP-tagged Cell Imaging", Q. Li, S. S. H. Wu, and K. C. Chou, Biophys. J . 97, 3224 (2009) PDF

8. “Selective Recognition of Rituximab-Functionalized Gold Nanoparticles by Lymphoma Cells Studied with 3D Imaging”, A. Weiss, T. C. Preston, J. Popov, Q. Li, S. Wu, K. C. Chou, H. M. Burt, M. B. Bally, and R. Signorell, J. Phys. Chem. C, 113, 20252 (2009) PDF

7. "Competitive adsorption of toluene and n-alkanes at binary solution/silica interfaces", Z. Yang, Q. Li, R. Hua, M. Gray, and K. C. Chou, J. Phys. Chem. C, 113, 20355 (2009) PDF

6. “Two-dimensional IR-visible sum frequency generation spectroscopy - a unique probe of surface electronic states at buried interfaces”, Q. Li and K. C. Chou, Physical Chemistry of Interfaces and Nanomaterials VIII, Proc. SPIE, 7396, 73960Q (2009)

5. "Structures of Water Molecules at the Interfaces of Aqueous Salt Solutions and Silica: Cation Effects", Z. Yang, Q. Li, and K. C. Chou, J. Phys. Chem. C 113, 8201 (2009) PDF

4. "Surface-enhanced IR-visible Sum Frequency Generation Vibrational Spectroscopy", Q. Li, C. W. Kuo, Z. Yang, P. Chen, and K. C. Chou, Phys. Chem. Chem. Phys. 11, 3436 (2009) PDF

3. "Nonlinear Optical Properties of Schiff Base-Containing Conductive Polymer Films Electrodeposited in Microgravity", A. Pietrangelo, B. C. Sih, B. N. Boden, Z. Wang, Q. Li, K. C. Chou, M. J. MacLachlan, M. O. Wolf, Adv. Mater. 20, 2280 (2008) PDF

2. "Electronic and Conformational Properties of the Conjugated Polymer MEH-PPV at a Buried Film/Solid Interface Investigated by Two-dimensional IR-visible Sum Frequency Generation", Q. Li, R. Hua, and K.C. Chou, J. Phys. Chem. B 112, 2315 (2008) PDF

1. "Surface Structure Relaxation of Poly(methyl methacrylate)", Q. Li, R. Hua, I. J. Cheah, and K. C. Chou, J. Phys. Chem. B 112, 694 (2008) PDF

 

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Contact

Real name: 
Email: 
Office Room Number(s): 
D348
Office Phone Number: 
604-822-5850
Fax Number: 
604-822-2847

Curriculum Vitae

2004-: University of British Columbia;

2001-2004: University of California, Berkeley (Postdoc);

1994-2001: University of California, Riverside (PhD, 2001);

1993-1994: Brown University;

1992,1993: L3 ExperimentCERN;

1991-1993: National Central University (MS, 1993);

1985-1989: Tunghai University (BS, 1989)

Publications

2015

Tsou, C. - J. ; Hsia, C. - H. ; Chu, J. - Y. ; Hung, Y. ; Chen, Y. - P. ; Chien, F. - C. ; Chou, K. C. ; Chen, P. ; Mou, C. - Y. Local Ph Tracking In Living Cells. Nanoscale 2015, 7, 4217-25.
Yang, Z. ; Nikakhtari, H. ; Wolf, S. ; Hu, D. ; Gray, M. R. ; Chou, K. C. Binary Solvents With Ethanol For Effective Bitumen Displacement At Solvent/mineral Interfaces. Energy & Fuels 2015.
Tafteh, R. ; Scriven, D. R. L. ; Moore, E. D. W. ; Chou, K. C. Single Molecule Localization Deep Within Thick Cells; A Novel Super-Resolution Microscope. Journal of Biophotonics 2015.

2014

Shih, J. - Y. ; Huang, W. - C. ; Ko, C. - T. ; Yang, Z. ; Hu, S. - H. ; Leu, J. ; Chou, K. C. ; Chen, K. - N. Adhesion Investigation Between Metal And Benzocyclobutene (Bcb) Polymer Dielectric Materials In 3-D Integration Applications. Ieee Transactions on Device and Materials Reliability 2014, 14, 914-920.

2013

Leung, J. P. ; Wu, S. ; Chou, K. C. ; Signorell, R. Investigation Of Sub-100 Nm Gold Nanoparticles For Laser-Induced Thermotherapy Of Cancer. Nanomaterials 2013, 3, 86-106.

2012

Leung, B. O. ; Yang, Z. ; Wu, S. S. H. ; Chou, K. C. Role Of Interfacial Water On Protein Adsorption At Cross-Linked Polyethylene Oxide Interfaces. Langmuir 2012, 28, 5724-5728.

2011

Leung, B. O. ; Chou, K. C. Review Of Super-Resolution Fluorescence Microscopy For Biology. Applied Spectroscopy 2011, 65, 967-980.
Yang, Z. ; Bertram, A. K. ; Chou, K. C. Why Do Sulfuric Acid Coatings Influence The Ice Nucleation Properties Of Mineral Dust Particles In The Atmosphere?. Journal of Physical Chemistry Letters 2011, 2, 1232-1236.

2010

Yang, Z. ; Li, Q. ; Gray, M. R. ; Chou, K. C. Structures Of Water Molecules At Solvent/silica Interfaces. Langmuir 2010, 26, 16397-16400.

2009

Yang, Z. ; Li, Q. F. ; Hua, R. ; Gray, M. R. ; Chou, K. C. Competitive Adsorption Of Toluene And N-Alkanes At Binary Solution/silica Interfaces. Journal of Physical Chemistry C 2009, 113, 20355-20359.
Yang, Z. ; Li, Q. F. ; Chou, K. C. Structures Of Water Molecules At The Interfaces Of Aqueous Salt Solutions And Silica: Cation Effects. Journal of Physical Chemistry C 2009, 113, 8201-8205.
Li, Q. F. ; Wu, S. S. H. ; Chou, K. C. Subdiffraction-Limit Two-Photon Fluorescence Microscopy For Gfp-Tagged Cell Imaging. Biophysical Journal 2009, 97, 3224-3228.
Li, Q. F. ; Kuo, C. W. ; Yang, Z. ; Chen, P. L. ; Chou, K. C. Surface-Enhanced Ir-Visible Sum Frequency Generation Vibrational Spectroscopy. Physical Chemistry Chemical Physics 2009, 11, 3436-3442.
Weiss, A. ; Preston, T. C. ; Popov, J. ; Li, Q. ; Wu, S. ; Chou, K. C. ; Burt, H. M. ; Bally, M. B. ; Signorell, R. Selective Recognition Of Rituximab-Functionalized Gold Nanoparticles By Lymphoma Cells Studied With 3D Imaging. Journal of Physical Chemistry C 2009, 113, 20252-20258.

2008

Pietrangelo, A. ; Sih, B. C. ; Boden, B. N. ; Wang, Z. W. ; Li, Q. F. ; Chou, K. C. ; MacLachlan, M. J. ; Wolf, M. O. Nonlinear Optical Properties Of Schiff-Base-Containing Conductive Polymer Films Electro-Deposited In Microgravity. Advanced Materials 2008, 20, 2280-+.
Li, Q. F. ; Hua, R. ; Cheah, I. J. ; Chou, K. C. Surface Structure Relaxation Of Poly(Methyl Methacrylate). Journal of Physical Chemistry B 2008, 112, 694-697.

2005

Stamenkovic, V. ; Chou, K. C. ; Somorjai, G. A. ; Ross, P. N. ; Markovic, N. M. Vibrational Properties Of Co At The Pt(111)-Solution Interface: The Anomalous Stark-Tuning Slope. Journal of Physical Chemistry B 2005, 109, 678-680.

2004

Westerberg, S. ; Wang, C. ; Chou, K. ; Somorjai, G. A. High-Pressure Ammonia Adsorption And Dissociation On Clean Fe(111) And Oxygen-Precovered Fe(111) Studied By Sum Frequency Generation Vibrational Spectroscopy. Journal of Physical Chemistry B 2004, 108, 6374-6380.
Chou, K. C. ; Westerberg, S. ; Shen, Y. R. ; Ross, P. N. ; Somorjai, G. A. Probing The Charge-Transfer State Of Co On Pt(111) By Two-Dimensional Infrared-Visible Sum Frequency Generation Spectroscopy. Physical Review B 2004, 69.

2003

Chou, K. C. ; Kim, J. ; Baldelli, S. ; Somorjai, G. A. Vibrational Spectroscopy Of Carbon Monoxide, Acetonitrile, And Phenylalanine Adsorbed On Liquid Vertical Bar Electrode Interfaces By Sum Frequency Generation. Journal of Electroanalytical Chemistry 2003, 554, 253-263.
Chou, K. C. ; Markovic, N. M. ; Kim, J. ; Ross, P. N. ; Somorjai, G. A. An In Situ Time-Dependent Study Of Co Oxidation On Pt(111) In Aqueous Solution By Voltammetry And Sum Frequency Generation. Journal of Physical Chemistry B 2003, 107, 1840-1844.
Kim, J. ; Chou, K. C. ; Somorjai, G. A. Structure And Dynamics Of Acetonitrile At The Air/liquid Interface Of Binary Solutions Studied By Infrared-Visible Sum Frequency Generation. Journal of Physical Chemistry B 2003, 107, 1592-1596.

2002

Hoffer, S. ; Baldelli, S. ; Chou, K. ; Ross, P. ; Somorjai, G. A. Co Oxidation On Electrified Platinum Surfaces In Acetonitrile/water Solutions Studied By Sum Frequency Generation And Cyclic Voltammetry. Journal of Physical Chemistry B 2002, 106, 6473-6478.

1999

Kwak, H. ; Chou, K. C. ; Guo, J. ; Tom, H. W. K. Femtosecond Laser-Induced Disorder Of The (1 X 1)-Relaxed Gaas(110) Surface. Physical Review Letters 1999, 83, 3745-3748.