Interrogating the thionium hydrogen bond as a noncovalent stereocontrolling interaction in chiral phosphate catalysis

CH⋯O bonds are a privileged noncovalent interaction determining the energies and geometries of a large number of structures. In catalytic settings, these are invoked as a decisive feature controlling many asymmetric transformations involving aldehydes. However, little is known about their stereochemical role when the interaction involves other substrate types. We report the results of computations that show for the first time thionium hydrogen bonds to be an important noncovalent interaction in asymmetric catalysis. As a validating case study, we explored an asymmetric Pummerer...


Oct 4 2022 - 12:45pm to 2:00pm
Dr. Becky Alexander
Department of Atmospheric Sciences, University of Washington
Oct 5 2022 - 1:00pm to 4:00pm
Lloyd Sibanda
UBC Chemistry (Huan Group)
Oct 11 2022 - 12:45pm to 2:00pm
Dr. Peter Mahaffy
Department of Chemistry, The King's University


Congratulations to Prof. Stephen Withers!

Professor Stephen Withers has been awarded the 2022 Haworth Memorial Lectureship from the RSC (Royal Society of Chemistry) Carbohydrate Group.


This award was founded in 1969 in commemoration of Sir Norman Haworth (president of the...

Parisa Mehrkhodavandi Has Been Named a 2022 Wall Scholar

Congratulations to Professor Parisa Mehrkhodavandi who has been selected to be a member of the 2022-23 Wall Scholars Catalyst cohort.

Members of the cohort will work together to initiate collaborations that engage the urgency, scale and...