Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


Dec 1 2021 - 10:00am to 11:00am
Prof. Corey Stephenson
Department of Chemistry, University of Michigan
Dec 3 2021 - 10:00am to 11:00am
Professor Corinna Schindler
Department of Chemistry, University of Michigan


November 2021 Chemistry Alumni Reunion

Our November 2021 Alumni Reunion was a great success! Thank you to all our attendees who joined us virtually and to Tao Huan and Emily Cheung for their inspiring talks.

This years event also featured the announcement of our Graduate...

Congratulations 2021 Graduate Student Award Winners!

Last week at our November 2021 Alumni Reunion, we announced this years Graduate Student Award winners- Congratulations to you all! Our winners are as follows:

Ed Shuter Scholarship - Kasra Asnaashari

Edward Piers Memorial Award in...