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Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: Ligand binding properties

TitleUnimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: Ligand binding properties
Publication TypeJournal Article
Year of Publication2008
AuthorsKainthan, RK, Mugabe, C, Burt, HM, Brooks, DE
JournalBiomacromolecules
Volume9
Pagination886-895
Date PublishedMar
ISBN Number1525-7797
Abstract

This paper discusses the binding and release properties of hydrophobically modified hyperbranched polyglycerol-polyethylene glycol copolymers that were originally developed as human serum albumin (HSA) substitutes. Their unimolecular micellar nature in aqueous solution has been proven by size measurements and other spectroscopic methods. These polymers aggregate weakly in solution, but the aggregates are broken down by low shear forces or by encapsulating a hydrophobic ligand within the polymer. The small molecule binding properties of these polymers are compared with those of,HSA. The preliminary in vitro paclitaxel release studies showed very promising sustained drug release characteristics achieved by these unimolecular micelles.

URL<Go to ISI>://000253926400018