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Site-specific prodrug release using visible light

TitleSite-specific prodrug release using visible light
Publication TypeJournal Article
Year of Publication2008
AuthorsJiang, MY, Dolphin, D
JournalJournal of the American Chemical Society
Volume130
Pagination4236-+
Date PublishedApr
ISBN Number0002-7863
Abstract

Using a photosensitization-singlet oxygenation-dioxetane cleavage strategy, a photodynamic prodrug system has been developed, whereby drugs bearing carbonyl groups can first be attached to a photosensitizer to give a photosensitizer-drug complex and then released from the complex upon visible light irradiation. Visible light, which has good penetration through tissue, generates singlet oxygen via the photosensitizer, which then releases the prodrug when and where required. With this system, drug mimics and methyl esters of NSAIDs have been successfully incorporated with photosensitizers related to verteporfin and then released by visible light illumination in high to quantitative yields within minutes.

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