Research & Teaching Faculty

Default Header Image

PHOTOSENSITIZING POTENCY OF STRUCTURAL ANALOGS OF BENZOPORPHYRIN DERIVATIVE (BPD) IN A MOUSE-TUMOR MODEL

TitlePHOTOSENSITIZING POTENCY OF STRUCTURAL ANALOGS OF BENZOPORPHYRIN DERIVATIVE (BPD) IN A MOUSE-TUMOR MODEL
Publication TypeJournal Article
Year of Publication1991
AuthorsRichter, AM, Waterfield, E, Jain, AK, Allison, B, Sternberg, ED, Dolphin, D, Levy, JG
JournalBritish Journal of Cancer
Volume63
Pagination87-93
Date PublishedJan
Type of ArticleArticle
ISBN Number0007-0920
KeywordsHEMATOPORPHYRIN, PHOTOFRIN-II, PHTHALOCYANINES, PLASMA-LIPOPROTEINS, porphyrins, TOXICITY
Abstract

The in vivo characteristics of four analogues of benzoporphyrin derivative (BPD) have been investigated. Biodistribution data obtained in DBA/2J mice with BPD-MA (monoacid ring A analogue) which had been tritiated or internally labelled with C-14 showed that both labelled materials acted in an essentially identical manner during the period of study. Biodistribution and clearance studies showed that relative distribution in a variety of mouse tissues was similar for all BPD analogues. M1 tumour cells (rhabdomyosarcoma in DBA/2J mice) taken from tumours excised from animals treated 3 h earlier with BPD, and tested in vitro for photosensitivity provided evidence that significant levels of photosensitiser detected in tumour was both active and associated with tumour cells. The monoacid forms of BPD were found to be much more photodynamically active in this test that were the diacid analogues. The ability of the analogues to ablate tumours in mice by photodynamic therapy was also tested. Again, BPD-MA and BPD-MB proved to be measurably better than the diacid analogues. These findings are discussed in reference to structural and physical differences between the analogues.

URL<Go to ISI>://A1991ER85300018