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PHASE-SEPARATION IN CYTOPLASM, DUE TO MACROMOLECULAR CROWDING, IS THE BASIS FOR MICROCOMPARTMENTATION

TitlePHASE-SEPARATION IN CYTOPLASM, DUE TO MACROMOLECULAR CROWDING, IS THE BASIS FOR MICROCOMPARTMENTATION
Publication TypeJournal Article
Year of Publication1995
AuthorsWalter, H, Brooks, DE
JournalFebs Letters
Volume361
Pagination135-139
Date PublishedMar
Type of ArticleArticle
ISBN Number0014-5793
KeywordsAQUEOUS PHASE SYSTEM, CELL CYTOPLASM, CYTOARCHITECTURE, CYTOPLASM, DIFFUSION, K+, LIVING CELL, MACROMOLECULAR CROWDING, MICROCOMPARTMENTATION, PHASE SEPARATION, TRANSLATIONAL MOBILITY, TRANSPORT
Abstract

The macromolecular diversity and concentrations in the fluid phase of cytoplasm constitute conditions necessary and sufficient for aqueous phase separation. Consequences of phase separation in cytoplasm, including its ’compartmentation’, are inferred from analogies with the physicochemical properties of aqueous two-phase systems and with the partitioning behavior of biomaterials in them.

URL<Go to ISI>://A1995QN70700001