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Nucleophilic additions of lactam-derived enol triflates to aldehydes mediated by nickel(II) and chromium(II) salts

TitleNucleophilic additions of lactam-derived enol triflates to aldehydes mediated by nickel(II) and chromium(II) salts
Publication TypeJournal Article
Year of Publication2004
AuthorsEaston, LP, Dake, GR
JournalCanadian Journal of Chemistry-Revue Canadienne De Chimie
Volume82
Pagination139-144
Date PublishedFeb
Type of ArticleArticle
ISBN Number0008-4042
KeywordsBOND FORMATIONS, BREVETOXIN-B, carbonyl addition, CATALYSIS, chromium(II) chloride, CONSTRUCTION, CYCLIZATION, DERIVATIVES, DYNEMICIN-A, ENANTIOSELECTIVE, lactam-derived enol triflate, LEPADIN B, NI(II)/CR(II)-MEDIATED COUPLING REACTION, nickel(II) chloride, TOTAL-SYNTHESIS
Abstract

Enol trifluoromethanesulfonates (triflates) derived from N-protected lactams undergo nickel(II)-chloride- and chromium(II)-chloride-promoted carbonyl additions to aldehydes. The yields of this process range from 42%-84%.

URL<Go to ISI>://000220138500010