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Liphagal, a selective inhibitor of PI3 kinase alpha isolated from the sponge Aka coralliphaga: Structure elucidation and biomimetic synthesis

TitleLiphagal, a selective inhibitor of PI3 kinase alpha isolated from the sponge Aka coralliphaga: Structure elucidation and biomimetic synthesis
Publication TypeJournal Article
Year of Publication2006
AuthorsMarion, F, Williams, DE, Patrick, BO, Hollander, I, Mallon, R, Kim, SC, Roll, DM, Feldberg, L, Van Soest, R, Andersen, RJ
JournalOrganic Letters
Volume8
Pagination321-324
Date PublishedJan
Type of ArticleArticle
ISBN Number1523-7060
KeywordsANALOGS, PHOSPHOINOSITIDE 3-KINASE INHIBITORS
Abstract

Liphagal (1), a selective inhibitor of PI3K alpha, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the constitution of liphagal (1) and support a proposed biogenesis.

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