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Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: Structure elucidation, synthesis, and biogenetic implications

TitleLatonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: Structure elucidation, synthesis, and biogenetic implications
Publication TypeJournal Article
Year of Publication2003
AuthorsLinington, RG, Williams, DE, Tahir, A, Van Soest, R, Andersen, RJ
JournalOrganic Letters
Volume5
Pagination2735-2738
Date PublishedJul
Type of ArticleArticle
ISBN Number1523-7060
KeywordsCOMPOUND, DEBROMOHYMENIALDISINE, HYMENIALDISINE, INHIBITION, STEVENSINE
Abstract

Latonduines A (6) and B (7), two new alkaloids with unprecedented heterocyclic skeletons, have been isolated from the Indonesian marine sponge Stylissa carted. The structures of the, latonduines were elucidated by analysis of spectroscopic data and confirmed by the total synthesis of latonduine A (6). It is proposed that ornithine is the biogenetic precursor to the aminopyrimidine fragment of the latonduines.

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