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THE ISOLATION OF MAJUSCULAMIDE-C FROM THE SPONGE PTILOCAULIS-TRACHYS COLLECTED IN ENEWETAK AND DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF THE 2-METHYL-3-AMINOPENTANOIC ACID RESIDUE

TitleTHE ISOLATION OF MAJUSCULAMIDE-C FROM THE SPONGE PTILOCAULIS-TRACHYS COLLECTED IN ENEWETAK AND DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF THE 2-METHYL-3-AMINOPENTANOIC ACID RESIDUE
Publication TypeJournal Article
Year of Publication1993
AuthorsWilliams, DE, Burgoyne, DL, Rettig, SJ, Andersen, RJ, Fathiafshar, ZR, Allen, TM
JournalJournal of Natural Products
Volume56
Pagination545-551
Date PublishedApr
Type of ArticleArticle
ISBN Number0163-3864
KeywordsAMINO-ACIDS, BIOACTIVE MARINE METABOLITES, CYCLIC DEPSIPEPTIDE, CYCLODEPSIPEPTIDES, LYNGBYA-MAJUSCULA, PEPTIDE, THEONELLA SP
Abstract

Majusculamide C [1], a cyclic depsipeptide metabolite of the blue-green alga Lyngbya majuscula, has been isolated from the sponge Ptilocaulis trachys collected at Enewetak Atoll in the Marshall Islands. The absolute configuration of the novel beta amino acid 2-methyl-3-aminopentanoic acid (MAP), a component of the structure of 1, has been determined to be 2S,3R.

URL<Go to ISI>://A1993KX56800015