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Incorporation of 8-histaminyldeoxyadenosine [8-(2-(4-imidazolyl)ethylamino)-2 ’-deoxyriboadenosine] into oligodeoxyribonucleotides by solid phase phosphoramidite coupling

TitleIncorporation of 8-histaminyldeoxyadenosine [8-(2-(4-imidazolyl)ethylamino)-2 ’-deoxyriboadenosine] into oligodeoxyribonucleotides by solid phase phosphoramidite coupling
Publication TypeJournal Article
Year of Publication2002
AuthorsLermer, L, Hobbs, J, Perrin, DM
JournalNucleosides Nucleotides & Nucleic Acids
Volume21
Pagination651-664
Type of ArticleArticle
ISBN Number1525-7770
KeywordsBEARING IMIDAZOLE, CATALYTIC REPERTOIRE, CLEAVAGE, DERIVATIVES, DNA, IMIDAZOLYL FUNCTIONALITIES, NUCLEIC-ACIDS, OLIGONUCLEOTIDES, RIBONUCLEASES, RNA
Abstract

The 3’ phosphoramidite of 8-histaminyl deoxyadenosine has been prepared and successfully incorporated into a short oligodeoxyribonucleotide. The synthetic methodology leading to this preparation is given and the implications for developing new DNAzymes as well as probing unusual nucleic acid structures are discussed.

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