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Improved separation of the curcuminoids, syntheses of their rare earth complexes, and studies of potential antiosteoporotic activity

TitleImproved separation of the curcuminoids, syntheses of their rare earth complexes, and studies of potential antiosteoporotic activity
Publication TypeJournal Article
Year of Publication2014
AuthorsMawani, Y, Orvig, C
JournalJ. Inorg. Biochem.
Volume132
Pagination52-58
Date PublishedMAR
ISSN0162-0134
Abstract

The first reported homogenous rare earth curcumin (HCurc; ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione)) complexes with the formula ML3, where M3+ is Eu(III), Gd(III) or Lu(III), were synthesized and characterized by mass spectrometry, infrared spectroscopy and, in the case of the lutetium complex, H-1 NMR spectroscopy. Most importantly an improved separation of the three curcuminoids, HCurc, HDMC ((lE,6E)-1-(4-hydroxy-3-methoxypheny1)-7-(4-hydroxyphenyl)hepta-1,6-dien e-3,5-dione) and HBDMC ((1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione) was realized using a combination of normal-phase column and phosphate-impregnated preparative-thin layer chromatographies. The toxicities of the metal curcumin complexes and ligands were investigated in MG-63 cells, an osteoblast-like cell line, for potential activity as antiosteoporotic agents. (c) 2013 Elsevier Inc. All rights reserved.

DOI10.1016/j.jinorgbio.2013.12.004
Refereed DesignationRefereed