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DMAP Promoted Tandem Addition Reactions Forming Substituted Tetrahydroxanthones

TitleDMAP Promoted Tandem Addition Reactions Forming Substituted Tetrahydroxanthones
Publication TypeJournal Article
Year of Publication2014
AuthorsCastillo-Contreras, EB, Dake, GR
JournalORGANIC LETTERS
Volume16
Pagination1642-1645
Date PublishedMAR 21
ISSN1523-7060
Abstract

Substituted tetrahydroxanthones are constructed using a DMAP-promoted tandem nucleophilic addition process. The reaction yields range from 39% to 73%. Disubstituted tetrahydroxanthones are generated as a similar to 2.3:1 mixture of diastereomers favoring the formation of the trans-isomer.

DOI10.1021/ol5002945