News & Events

Designing Targeted Oxine-Based Ligands for ImmunoPET Imaging

Wednesday, April 6, 2022 - 17:00 to 18:00
Lily Southcott
Department of Chemistry, University of British Columbia
Event Category: 
IDG - Inorganic Discussion Group
Chris Orvig
Chemistry D300

IDG seminars will be held in D300 and also available on zoom this term. Please contact for zoom details.

Nuclear medicine exploits the decay properties of radioisotopes for diagnostic imaging and cancer therapy and as more isotopes are available, research has shifted to focus on safely administering radiometal ions biologically. Developing novel radiometal-containing pharmaceuticals requires designing chelators capable of forming highly thermodynamically stable and kinetically inert complexes. Using 8-hydroxyquinoline as the main donor group in a series of ligands, new, high denticity ligands have been synthesized, characterized, and preliminary radiochemistry abilities evaluated. Further adapting said chelators with antibodies as targeting vectors allows for improved target uptake and disease specificity. This seminar will discuss a proof-of-concept study to outline the chelate design process from synthesis to antibody functionalization, and the investigate the radiolabeling effects and in vitro and in vivo stability and distribution.