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A critical investigation of the effects of the radio frequency potential on the trapping of externally injected ions in ion trap mass spectrometry

TitleA critical investigation of the effects of the radio frequency potential on the trapping of externally injected ions in ion trap mass spectrometry
Publication TypeJournal Article
Year of Publication1999
AuthorsRobb, DB, Blades, MW
JournalRapid Communications in Mass Spectrometry
Volume13
Pagination1079-1087
Type of ArticleArticle
ISBN Number0951-4198
KeywordsDESORBED IONS, FIELDS, LASER-DESORPTION IONIZATION, OF-FLIGHT DEVICE, QUISTOR, SAMPLES, SIMULATION, STORE
Abstract

The sensitivity of all ion trap mass spectrometry (ITMS) methods is dependent on the trapping efficiency of the instrument. For ITMS instruments utilizing external ion sources, such as laser desorption, trapping efficiency is known to depend on the phase and amplitude of the radio frequency (RF) potential applied to the ring electrode at the time of ion introduction. It is remarkable that, in a considerable body of literature, no consensus exists regarding the effects of these parameters on the efficacy of trapping externally generated ions, In this paper, a summary of the literature is presented in order to highlight significant discrepancies. New laser desorption ion trap mass spectrometry (LD-ITMS) data are also presented, from which conclusions are drawn in our effort to clarify some of the confusion. Copyright (C) 1999 John Wiley & Sons, Ltd.

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