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Coordination chemistry and insulin-enhancing behavior of vanadium complexes with maltol C6H6O3 structural isomers

TitleCoordination chemistry and insulin-enhancing behavior of vanadium complexes with maltol C6H6O3 structural isomers
Publication TypeJournal Article
Year of Publication2005
AuthorsSaatchi, K, Thompson, KH, Patrick, BO, Pink, M, Yuen, VG, McNeill, JH, Orvig, C
JournalInorganic Chemistry
Volume44
Pagination2689-2697
Date PublishedApr
Type of ArticleArticle
ISBN Number0020-1669
Keywordsaluminum, BIS(MALTOLATO)OXOVANADIUM(IV), CRYSTAL-STRUCTURE, DIABETIC-RATS, ISOMALTOL, LIGANDS, REFINEMENT, SPECIATION, therapy, VANADATE
Abstract

Syntheses of vanadium complexes using the naturally occurring ligands isomaltol (Hima) and allomaltol (Hama), as well as a newly synthesized, potentially tetradentate diaminodipyrone [H-2(en(ama)(2)], are reported. Complete characterization of the resulting compounds [trans-VO(ima)(2)(H2O), VO(ama)(2), V(ima)(3), V(ama)(3) and VO(en(ama)(2))], including X-ray crystallography analyses for trans-VO(ima)(2)(H2O) and V(ima)3, are presented herein. Potentiometric titrations (25 degrees C, / = 0.16 M NaCl) were used to measure stability constants in the V(IV)-Hima system; these data were compared to previous data collected on the V(IV)-L (L = Hma, Hama) systems. The in vivo efficacy of these compounds to lower the blood glucose levels of STZ-diabetic rats was tested; all but VO(en(ama)2) produced significant decreases in plasma glucose levels. The results were compared to those of the benchmark compound BMOV [VO(ma)(2), bis(maltolato)oxovanadium(IV)], a known insulin-enhancing agent.

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