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An Approach to the Bis-oxazole Macrocycle of Diazonamides

TitleAn Approach to the Bis-oxazole Macrocycle of Diazonamides
Publication TypeJournal Article
Year of Publication2011
AuthorsZhang, J, Ciufolini, MA
JournalORGANIC LETTERS
Volume13
Pagination390-393
Date PublishedFEB 4
ISSN1523-7060
Abstract

A convergent approach to a macrocyclic compound embodying the complete ``eastern{''} quadrant of diazonamides is described. The opening sequence in this work relies on an oxazole-forming reaction devised earlier in this group, while a late step involves a Robinson-Gabriel cyclization of an amidoketone to form a second oxazole.

DOI10.1021/ol102678j