@article {4499,
	title = {UDP-glucose analogues as inhibitors and mechanistic probes of UDP-glucose dehydrogenase},
	journal = {Journal of Organic Chemistry},
	volume = {64},
	number = {26},
	year = {1999},
	note = {ISI Document Delivery No.: 271NJTimes Cited: 15Cited Reference Count: 25},
	month = {Dec},
	pages = {9487-9492},
	type = {Article},
	abstract = {UDP-glucose dehydrogenase catalyzes the NAD(+)-dependent 2-fold oxidation of UDP-glucose to give UDP-glucuronic acid. The putative aldehyde intermediate is not released from the active site and is presumably tightly bound. We have prepared UDP-7-deoxy-alpha-D-gluco-hept-6-ulopyranose 5, that contains a methyl ketone at C-6 and cannot be further oxidized by the enzyme. Ketone 5 was found to be a competitive inhibitor of the dehydrogenase from Streptococcus pyogenes with a K-I value of 6.7 mu M. We have also prepared the secondary alcohols UDP-6S-6C-methylglucose, 4a, and UDP-6R-6C-methylglucose, 4b. Compound 4a, but not 4b, was found to be a slow substrate for the dehydrogenase and was converted into the ketone inhibitor 5. This is consistent with the notion that the pro-R hydride is transferred in the first oxidation step of the normal enzymatic reaction.},
	keywords = {EFFICIENT SYNTHESIS, FUCOSE, GROUP-A STREPTOCOCCI, nucleotides, POLYSACCHARIDE, VIRULENCE},
	isbn = {0022-3263},
	url = {<Go to ISI>://000084600100019},
	author = {Campbell, R. E. and Tanner, M. E.}
}
@article {3923,
	title = {Uridine diphospho-alpha-D-gluco-hexodialdose: Synthesis and kinetic competence in the reaction catalyzed by UDP-glucose dehydrogenase},
	journal = {Angewandte Chemie-International Edition in English},
	volume = {36},
	number = {13-14},
	year = {1997},
	note = {ISI Document Delivery No.: XR042Times Cited: 9Cited Reference Count: 29},
	month = {Aug},
	pages = {1520-1522},
	type = {Article},
	keywords = {carbohydrates, enzyme catalysis, GROUP-A STREPTOCOCCI, intermediates, nucleotides, VIRULENCE},
	isbn = {0570-0833},
	url = {<Go to ISI>://A1997XR04200042},
	author = {Campbell, R. E. and Tanner, M. E.}
}
