@article {doi:10.1002/anie.201709532,
	title = {An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy},
	journal = {Angewandte Chemie International Edition},
	volume = {56},
	number = {46},
	year = {2017},
	pages = {14712-14717},
	abstract = {Abstract The 18-membered macrocycle H2macropa was investigated for 225Ac chelation in targeted alpha therapy (TAT). Radiolabeling studies showed that macropa, at submicromolar concentration, complexed all 225Ac (26 kBq) in 5 min at RT. [225Ac(macropa)]+ remained intact over 7 to 8 days when challenged with either excess La3+ ions or human serum, and did not accumulate in any organ after 5 h in healthy mice. A bifunctional analogue, macropa-NCS, was conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. Both constructs rapidly radiolabeled 225Ac in just minutes at RT, and macropa-Tmab retained >99 \% of its 225Ac in human serum after 7 days. In LNCaP xenograft mice, 225Ac-macropa-RPS-070 was selectively targeted to tumors and did not release free 225Ac over 96 h. These findings establish macropa to be a highly promising ligand for 225Ac chelation that will facilitate the clinical development of 225Ac TAT for the treatment of soft-tissue metastases.},
	keywords = {actinium, CANCER, Chelates, macrocycles, RADIOPHARMACEUTICALS},
	doi = {10.1002/anie.201709532},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201709532},
	author = {Thiele, Nikki A. and Brown, Victoria and Kelly, James M. and Amor-Coarasa, Alejandro and Jermilova, Una and MacMillan, Samantha N. and Nikolopoulou, Anastasia and Ponnala, Shashikanth and Ramogida, Caterina F. and Robertson, Andrew K. H. and Rodr{\'\i}guez-Rodr{\'\i}guez, Cristina and Schaffer, Paul and Williams Jr., Clarence and Babich, John W. and Radchenko, Valery and Wilson, Justin J.}
}
@article {2494,
	title = {N,O-Chelates of Group 4 Metals: Contrasting the Use of Amidates and Ureates in the Synthesis of Metal Dichlorides},
	journal = {European Journal of Inorganic Chemistry},
	number = {18},
	year = {2009},
	note = {ISI Document Delivery No.: 467LNTimes Cited: 5Cited Reference Count: 69Leitch, David C. Beard, J. David Thomson, Robert K. Wright, Vincent A. Patrick, Brian O. Schafer, Laurel L.},
	month = {Jun},
	pages = {2691-2701},
	type = {Article},
	abstract = {A series of dichloride complexes of titanium and zirconium with amidate and ureate ancillary ligands have been prepared, Three examples of bis(amidate)dichlorotitanium and zirconium complexes were effectively synthesized through salt metathesis with metal tetrachloride as starting materials. Optimum results were achieved using sodium amidate salts formed from sodium bis(trimethylsilyl)amide and neutral amide proligands, while other methods were ineffective. Use of electron-donating ureate ligands in lieu of amidates enables preparation through alternate routes. Protonolysis of Ti(NMe2)(2)Cl-2 and Zr(NMe2)(2)Cl-2(dme) with urea proligands leads to dichlorobis(ureate) complexes in good yield. Using a tethered bis(ureate) ligand eliminates the fluxional behaviour and coordination isomerism observed for both bis(amidate) and bis(ureate) zirconium complexes. ((C) Wiley-VCH Verlag GmbH \& Co. KGaA, 69451 Weinheim, Germany, 2009)},
	keywords = {amidate, BIS(AMIDATE) TITANIUM PRECATALYST, CATALYTIC, Chelates, COORDINATION CHEMISTRY, EARLY, GUANIDINATE LIGANDS, HYDROAMINATION, INTERMOLECULAR HYDROAMINATION, N, O ligands, OLEFIN POLYMERIZATION, SOLUTION DYNAMICS, STRUCTURAL-CHARACTERIZATION, TITANIUM, TRANSITION-METALS, Ureate, ZIEGLER-NATTA POLYMERIZATION, ZIRCONIUM},
	isbn = {1434-1948},
	url = {<Go to ISI>://000267740500015},
	author = {Leitch, D. C. and Beard, J. D. and Thomson, R. K. and Wright, V. A. and Patrick, B. O. and Schafer, L. L.}
}
@article {4851,
	title = {Diphenylboron complexes of the enol tautomers of arylpyruvic acids. Crystal and molecular structure of triethylammonium (2-nitrophenyl)pyruvato-diphenylboron(1-)},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {78},
	number = {5},
	year = {2000},
	note = {ISI Document Delivery No.: 318FFTimes Cited: 2Cited Reference Count: 28},
	month = {Aug},
	pages = {546-552},
	type = {Article},
	abstract = {{Synthesis has been carried out of 15 examples of anionic diphenylboron complexes of arylpyruvic acids, and the structures of the compounds have been determined from spectroscopic data and from X-ray analysis of one of the compounds. Crystals of 5j are monoclinic, P2(1)/n},
	keywords = {arylpyruvic acids, boron complexes, Chelates, crystal structure, diphenylboron, enol tautomers, organoborate salts, PHENYLPYRUVIC ACID},
	isbn = {0008-4042},
	url = {<Go to ISI>://000087272700005},
	author = {Kliegel, W. and Pokriefke, J. O. and Rettig, S. J. and Trotter, J.}
}
@article {4561,
	title = {Reaction of diphenylborinic acid with pyridinium and phosphonium bisacyl methylides. Crystal and molecular structures of resulting B,N- and B,P-betaines},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {77},
	number = {4},
	year = {1999},
	note = {ISI Document Delivery No.: 204JXTimes Cited: 8Cited Reference Count: 27},
	month = {Apr},
	pages = {439-450},
	type = {Article},
	abstract = {{Reaction of pyridinium and phosphonium 2-carboxy-1-formyl-2-oxoethylides with oxybis(diphenylborane) yields 5-(2-oxo-1-(pyridinio or phosphonio)ethylidene)-2,2-diphenyl-1,3-dioxa-2-borata-4-cyclopentanones , which represent novel types of boron nitrogen and boron phosphorus betaines, respectively. Crystals of 5-(2-oxo-1-pyridinioethylidene)-2,2-diphenyl-1,3-dioxa-2-borata-4-cyclop entanone, 1a, are monoclinic},
	keywords = {bisacyl methylide diphenylboron, BOND, BORON, boron nitrogen betaines, boron phosphorus betaines, Chelates, crystal structures, ORGANOBORON COMPOUNDS, phosphonium ylides, pyridinium ylides},
	isbn = {0008-4042},
	url = {<Go to ISI>://000080762100005},
	author = {Grunefeld, J. and Kliegel, W. and Rettig, S. J. and Trotter, J.}
}
